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However, when alveolar cell lines are treated with cigarette smoke condensate an increase in the hypomethylation of transcriptional enhancer markers located adjacent to cg05575921 was found, 86 suggesting that cg05575921 and other sites in AHRR may be actively involved in the induction of gene regulatory elements

Fuchs CS, et al

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Over the years, many studies have assessed the impact of smoking on the risk of developing dementia later in life