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For example, mutations of p53 , mutations or loss of liver kinase B1 ( LKB1 ) (also known as serine/threonine kinase 11 ( STK11 )), which is frequently associated with the loss of Kelch-like ECH-associated protein 1 ( KEAP1 ), and bi-allelic inactivation of cyclin-dependent kinase inhibitor 2A ( CDKN2A ) and cyclin-dependent kinase inhibitor 2A ( CDKN2B ) have been identified as three major co-occurring genetic alterations in KRAS -mutant LUAD

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While the symbolism of the cigarette, pipe and cigar respectively were consolidated in the late 19th century, it was not until the 20th century that artists began to use it fully

Aggarwal M, Saxena R, Sinclair E, Fu Y, Jacobs A, Dyba M, et al