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1) The group level BEN difference between the smokers and the controls was assessed with the massive univariate two-sample t-test implemented in SPM8 using the spatially normalized BEN maps

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(See paragraph (c)(4)(ii) of this section for an illustrative, non-exhaustive list of nonquantitative treatment limitations.) A complete exclusion of all benefits for a particular condition or disorder, however, is not a treatment limitation for purposes of this definition

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