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There are thousands of ingredients in every smoke More than 4000 ingredients are in every cigarette, creating 200 "compound chemicals." Of these, at least 60 are known to cause cancer and include arsenic, formaldehyde, and hydrogen cyanide, used in Nazi gas chambers

However, with federal regulation of e-cigarettes in place and an uncertain future as many remain under premarket review, some vape shops are now shifting to smoke shops (that sell both vape products and other tobacco products and accessories), diversifying their offerings to include a variety of tobacco products and (un- or under-regulated) cannabis-based products as well as kratom, as well as a growing their online retail segment, which can undermine federal, state and local restrictions on product sales in the retail environment, including youth access