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In addition, the strength of the study relies on its analysis with well-adjusted cofactors, including age, estimated glomerular filtration rate, diabetes, dyslipidemia, body mass index, smoking status, physical activity, family history, and systolic blood pressure

Data published in October 2025 suggest that an estimated 1.6% of adults in England used oral nicotine pouches, equating to around 777,000 people, while 14.2% used vapes and 15% smoked cigarettes 3,4

This again is based on a different endpoint (increase of blood pressure in this case, which is expected to be more sensitive than mortality)