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Here, we showed that nicotine-activated neutrophils secrete glycoprotein lipocalin-2 (LCN2) which facilitate functional reversion of mesenchymal cancer cells into epithelial phenotype (MET) in a paracrine manner which is an essential step for metastatic colonization as previously described 130

The effect of smoking cessation was studied by Tomita et al ., and it was observed that the SUA levels (6.18 mg/dL) were the highest among the ex-smokers, followed by the levels in never-smokers (6.10 mg/dL), and the least in the levels of the current smokers (5.98 mg/dL).[] Even though cessation of smoking can be the best recommended intervention among the smokers, the effect of uric acid supplementation was studied by Waring et al