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If you smoke multiple times a day: If you smoke many times each day, THC might stay in your system for 30 days or more

associated with human dependence DOPAMINE Pleasure, Appetite Suppression NOREPINEPHRINE Arousal, Appetite Suppression ACETYLCHOLINE Arousal, Cognitive Enhancement GLUTAMATE Learning, Memory Enhancement SEROTONIN Mood Modulation, Appetite Suppression BETA-ENDORPHIN Reduction of Anxiety and Tension GABA Reduction of Anxiety and Tension NICOTINE b2 b2 a4 a4 b2 4b2 nAChR Dopamine GABA GLU Nicotine Addiction: Reinforcing Behavior nicotine Nicotine activates nAChRs on DA and GABA neurons (VTA) and Glu neurons Net result of stimulatory and inhibitory effects and differential desensitization of nAChRs is enhanced DA release in the n

Beyond disease onset, smoking appears to negatively influence disease course in PBC

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