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Clofazimine is at least partially metabolised in the liver via CYP3A4 and CYP1A2, thereby TB smokers may experience increased metabolite synthesis, potentially necessitating dosage adjustments

Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption

Notably, tobacco smoking represents a significant promoting factor in TB progression, being associated with poorer treatment outcomes, delayed conversion to negative smear or culture, and higher dropout rates from treatment plans

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