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Evidence suggests multiple interrelated pathways of liver injury: Nicotine-induced injury : Nicotine is metabolized in the liver via CYP2A6, where it activates 7-nicotinic acetylcholine receptors (7-nAChR), leading to oxidative stress, mitochondrial dysfunction, and pro-fibrotic signaling [36, 125, 126]

Staying hydrated, using humidifiers, and opting for alternative consumption methods like edibles or vaping can help minimize throat irritation

"We spent a few decades fighting Big Tobacco in the form of cigarettes," Walton said

Once the e-liquid is depleted or the battery life ends, the disposable vape can be discarded