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3 Nicotine pharmacology and cardiovascular effects 3.1 Mechanisms of nicotine action As detailed by Benowitz (22) in his comprehensive review of nicotine pharmacology, nicotines addictive potential stems from its complex interaction with the nervous system, involving rapid central nervous system penetration and subsequent activation of neural reward pathways
Eur J Pharmacol
They calculated that smokers were likely to die 6.5 years earlier than non-smokers
In contrast, cannabis primarily contains THCa psychoactive substance without the physically addictive properties of nicotine
