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E-cigarettes, invented in 1965, hit the U.S
- Change to Winston and change for good
of Health and Human Services in April of 1994 listing the 599 additives approved by the United States Government for use in the manufacture of cigarettes

Since cigarette smoke is known to modulate expression and activity of the maintenance methyltransferase DNMT1, actively dividing cells may be more susceptible to exposure-mediated defects in DNA methylation
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