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It isnt processed by liver enzymes called CYP450, which are often affected by cannabis. This might help explain why side effects seem lower when gabapentin and cannabis are used together, but that doesnt mean the combination is always safe

To note, similar reductions in endothelial-dependent dilation have been identified after a single exposure to combustible tobacco products or e-cigarettes [115], although contradictory results are also available, supporting that acute exposure to neither combustible tobacco cigarettes nor ENDS had an effect on vascular function [87]