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The genetic component of RA is widely investigated [36]: the strongest gene association is considered to be the one with the human leukocyte antigen (HLA) region, particularly the HLA-DRB1 genes accounting for about two-thirds of the genetics of RA

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In addition, while the initial cost of the heat-not-burn device is around 30, using these products over time will be far less expensive than smoking traditional cigarettes, with a pack of tobacco sticks costing less than half the average price of a pack of cigarettes*