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The detection of an antigen by specialized cells known as Mcells is the first step in inducing a mucosal immune response (Fragoso et al., 2017)

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[108] [109] Guinea-Bissau [edit] In Guinea-Bissau, a 2017 survey of 2,039 adolescents aged 14 to 19, distributed across 16 schools, found that 14.8% had experimented with cigarettes at some point in their lives, 4.0% were occasional smokers, and 2.4% were daily smokers