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Chemicals in cigarette smoke: speed up the formation of plaque on blood vessel walls resulting in atherosclerosis (narrowing of the arteries) thicken the blood and make it sticky and more likely to clot tighten the blood vessels which restricts blood flow and increases blood All of this leads to an increased risk of stroke, both for you and any non-smokers you live with

Model building, refinement and analysis Atomic models were manually built and refined with Coot (version 0.9.8.7) 86 , whereas degrader coordinates and the corresponding restraints applied during model refinement were generated using the JLigand 87 interface

We hope its peers quickly follow suit

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