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Study characteristics, including geographical location (continents), ethnicity, gender, country income level, study quality, outcome definition, the proportion of current and female smokers, sample size and year, were utilised for explanatory meta-regression models (Table S8)

Pulmonary infection diagnosis criteria Pneumonia was defined by the presence of a new or progressive infiltration on chest radiography or computed tomography (CT), together with any of the following: purulent sputum and fever [8]

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