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4 As patterns of use increase, nicotine causes more significant changes in brain neural circuitry, resulting in a lower sensitivity to nicotines aversive properties, and reinforcing the pathways that drive regular intake, e.g
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The EMBO 2003, 22 , 33543, Kumar S, Dubey AK, Karmakar R, Kini KR, Mathew MK, Prakash HS
Pediatr Allergy Immunol 23: 472478
