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The pipe itself, as a means of smoking tobacco, had a much earlier appearance
A network meta-analysis performed in 2013 analyzed 63 RCT of nicotine medications including 21 NRT studies, 28 bupropion studies and 18 varenicline studies and found no significant increase in major adverse CV events (death, myocardial infarction, or stroke) with any of the three therapies, but a slight increase in less serious CV events (e.g
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For instance, in 2009, the U.S
