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Finally, mean 3-EP levels were higher when the smell of tobacco smoke was stronger (B=0.08

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Skin from his neck was used to replace his cheek, which was riddled with cancer

This combined criterion must be present together with the other major criterion, i.e., generalized JHM (gJHM) assessed with the Beighton score (BS) [15], and/or with at least three of the following minor criteria: easy bruising, soft, doughy skin, skin fragility, molluscoid pseudotumors, subcutaneous spheroids, hernia (or a history of thereof), epicanthal folds, JHM complications (sprains, luxation/subluxation, pain, flexible flatfoot), and family history of a first degree relative who meets clinical criteria [1, 16]