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Even though individual cigarettes pack up to 10mg of nicotine, only 1mg is absorbed into the smokers body

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Polycyclic aromatic hydrocarbons contained in Cigarette smoke increase the activity of CYP 1A2 enzymes, and thus affects the metabolism of its substrates, several antipsychotics, e.g., olanzapine, haloperidol, clozapine, as well as some antidepressants (amitriptyline, clomipramine, doxepin, duloxetine, fluvoxamine, imipramine, mianserin, mirtazapine) and benzodiazepines (64)

1 Smoking causes blood vessels throughout the body to narrow and stiffen, known as arteriolar sclerosis