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Effect of Volatile Organic Compounds on Intestinal Microbiota Cigarette smoke contains large amounts of toxic volatile organic compounds (VOCs), such as isoprene, acrylonitrile, 1, 3-butadiene, acrylonitrile, styrene and benzene, which are inhaled into respiratory tract and induce different diseases, such as respiratory and cardiovascular diseases, and cancers ( Helicobacter were significantly increased in the cecal contents and feces of mice ( Effect of Aldehydes on Intestinal Microbiota Aldehydes, such as saturated (acetaldehyde) and unsaturated (acrolein and croton-aldehyde) compounds, are extremely toxic owing to their high reactivity and induce various disorders and diseases in humans and animals (Table 1

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Inflammation and cancer Many cancers arise in areas of chronic inflammation, which plays a major role in tumor invasion, progression, and metastasis, largely through the cytokine-mediated activation of mechanisms involved in tissue repair, cell proliferation and angiogenesis [20, 22, 51,52,53]