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J Clin Epidemiol, 44(11):1271127-1271188

Gutkha is sweet in taste, and children consider it to be a form of candy
The hazards of smoking and the benefits of cessation: a critical summation of the epidemiological evidence in high-income countries

Minor contributions to drug metabolism have been observed in vitro from CYP1A1, CYP2C8, and CYP2C18, though these enzymes are less relevant in vivo due to their lower hepatic expression compared to CYP3A4 (Shimada et al., 1994)