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in US Patent US005608105A (1997)

Symptoms include Vomiting Incoordination Abnormal heart rate Abnormal respiratory rate Uncontrolled urination Uncontrolled defecation Overstimulation Agitation Hyperexcitability Tremors Seizures Paralysis Collapse Coma Death Some dogs react to tobacco poisoning by first becoming hyperexcitable and then become depressed

Animal models of schizophrenia typically fit into four different induction categories including drug-induced, lesion or genetic manipulation, and developmental studies [100]

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