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We narrowed down the gene sets to ten main cancer related pathways 40 , including cell cycle, signaling by Hippo, signaling by NOTCH, signaling by WNT, transcriptional regulation by TP53, MYC signaling, signaling by TGF-beta family members, cellular responses to stress, signaling by receptor tyrosine Kinases, PI3K cascade, and presented the Z -score generated by SPPA algorithm for these ten main pathways (Fig

[6] Although the company pushed towards lower tar content in its brands, it hasn't been shown that lower tar content is any less harmful

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