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Proteins which were hypophosphorylated at all time points included MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK) at Thr223 (0.3-fold), Fibroblast Growth Factor Receptor 1 Oncogene Partner (FGFR1OP) at Thr70 (0.4-fold), Eukaryotic Translation Elongation Factor 2 (EEF2) at Thr435 (0.4-fold), Methyl-CpG Binding Protein 2 (MECP2) at Ser229 (0.7-fold) echinoderm microtubule-associated protein-like 1 (EML1) at Ser160 (0.4-fold), and mediator of RNA polymerase II transcription subunit 1 (MED1) at Ser1156 (0.4-fold) (Supplementary Figure 2B)

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These three underpin our everyday ability to remember and learn, without which independent living would be much more difficult