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LiuLLiuFKouHZhangBJXuDChenBet alPrenatal nicotine exposure induced a hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic programmed alteration in intrauterine growth retardation offspring rats
(accessed January 15, 2023)

One feels a need to take more and more when the level of nicotine decreases, and the restlessness sets back in, and it follows this pattern: stress-nicotine-relief-withdrawal-stress
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