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Some other possible side effects of oral or injectable clindamycin include: abdominal pain toxic epidermal necrolysis (TEN) Stevens-Johnson syndrome (SJS) irritation of the esophagus nausea and vomiting allergic skin reactions severe allergic reactions inflammation of the vagina fluid buildup under the skin impeded liver function impeded kidney function blood disorders disrupted function of the immune system arthritis People using a clindamycin solution or lotion for acne may report skin-related side effects, including: For example, when an individual uses Clindagel for acne, the most common side effects are itchiness and skin peeling