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In 1957 Readers Digest published a series of articles that correctly reported a link between tar, tobacco, nicotine and cancer

A more conservative p value of less than .01 was considered statistically significant for all analyses due to the number of tests conducted

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This process ensures that appropriate safety nets and regulatory safeguards are put in place to mitigate health and social harms, especially in cases where there are observed gaps in the current regulatory framework for emerging substances like synthetic cannabinoids