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By 2022, the number of HTP users had more than doubled, with 17.9% of men and 6% of women using the safer nicotine product.[xiii] As previously noted, smoking rates had been falling for a number of years in Japan, but the speed of this decline accelerated after the introduction of HTP

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[67] All other clinically indicated respiratory infectious disease testing (e.g., urine antigen for Streptococcus pneumoniae and Legionella, sputum culture if productive cough, bronchoalveolar lavage culture if done, blood culture, human immunodeficiency virusrelated opportunistic respiratory infections if appropriate) must be negative and [67] No evidence in medical record of alternative plausible diagnoses (e.g., cardiac, rheumatologic, or neoplastic process)

National Fire Protection Association, Quincy Ahrens M (2013) Home structure fires