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Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production
Also not included above are costs from smokeless or spit tobacco use, adult secondhand smoke exposure, or pipe/cigar smoking
The most rigorous systematic reviews, which pool data from multiple randomized controlled trials, now provide strong evidence that nicotine e-cigarettes are more effective than traditional NRT (such as patches, gum, or lozenges) at helping people quit smoking entirely
