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Although p53 induces apoptosis in response to severe UVR-induced damage, UVR also activates AKT pathways that can counteract p53-mediated apoptosis through AKT-dependent phosphorylation of MDM2, resulting in increased MDM2 stability and malignant transformation of skin cells

The agency also will continue efforts to assist industry in complying with federal tobacco regulations through online information and webinars

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