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Those using harder drugs 10 times or more in the past year rose from 3% to 8%

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Compared to the livers of controls, livers of acetone-exposed rats showed increases in CYP content, microsomal biotransformation activity, peroxisomal fatty acid oxidation, and catalase activity and decreases in hepatic activity of superoxide dismutase and glutathione peroxidase without altering glutathione and malondialdehyde content