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However, the melanin already deposited in the deeper layers of the lip tissue does not disappear by itself, particularly in moderate to severe cases where pigmentation has built up over years

For individuals with MCAS or histamine intolerance, the decision to use nicotine must also balance these benefits against possible risks, such as overstimulation of the nervous system or unpredictable individual reactions

Plus, while manageable, IUD insertion and removal are still medical procedures, and the insertion in particular can be painful
But there are a few other conditions that can cause the same sensation
