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For example, in a recent modeling study, Apelberg and colleagues (2018) assessed the impact that reducing the nicotine content in cigarettes to minimally addictive levels would have on smoking cessation

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Roles for nigrostriatal--not just mesocorticolimbic--dopamine in reward and addiction

According to the majority of studies, early (1214 years) to mid (1517 years), is a critical risk period for the initiation of substance use and the onset of substance use is most likely to occur during this phase [6] because this is the time when peoples neural circuits, or brain pathways, that allow them to feel motivated and have rewarding experiences, are still active and growing [12] and regarding the parts of the brain that react mainly to new stimuli, the teenage and adult brains seem to be different