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While genetic susceptibility and environmental factors play a pathophysiologically important role in the development of SLE 1 , studies addressing how these factors are related to the occurrence and flare of the disease have yielded interesting yet inconsistent results

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2014, titled Long-term effects of marijuana use on the brain, demonstrated these structural changes, which suggest that long-term marijuana use has lasting impacts on brain health, particularly in individuals who began using marijuana at a young age

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