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An analysis of evidence from multiple scientific studies found six substances that have a strong link to bladder cancer in the urine of people who had used electronic cigarettes and sometimes other tobacco products, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and NYU Langone Health reported

Renal tubular damage or dysfunction could promote the nucleation, aggregation, and retention of crystals in the kidneys, eventually leading to the development of kidney stones (44)

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