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And if you look at how many cigarette packs are in a carton, the answer is simply easier, and most of the cigarette enthusiasts and manufacturers know it

Department of Health and Human Services (2014)

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Maternal smoking during pregnancy was found to significantly reduce the methylation of the gene PRDM8 (PR domain contain 8), which is a gene thats tightly regulated in a spatiotemporal manner during neural development and is important for regulating the morphological transition in neocortical development [4953]