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Endotoxemia as a Mechanism of Tobacco-Induced Damage One central mechanism underlying tobacco-related harm is endotoxemia, characterized by elevated lipopolysaccharide (LPS) levels resulting from the presence of Gram-negative bacteria in the bloodstream

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Advertising, marketing and promotional activities were curtailed, and the tobacco industry was banned from using cartoons, transit advertising and most forms of outdoor advertising to promote products

[155] Concerns have been raised that non-combustible nicotine products could lead adolescents and young adults to start smoking cigarettes later on