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These factors, combined with the regions established consumer base and regulatory frameworks, make Europe not only the largest market by volume but also strategically critical for global e-cigarette manufacturers navigating evolving public health policies

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165 Part Two: Biological and Clinical Endpoints in the Upper Aerodigestive Tract Basic Research on Ecigs in Otolaryngology Several studies have evaluated the effect of ecigs in cell, organoid, and animal models of the upper aerodigestive tract (Table 1)