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For example, mutations of p53 , mutations or loss of liver kinase B1 ( LKB1 ) (also known as serine/threonine kinase 11 ( STK11 )), which is frequently associated with the loss of Kelch-like ECH-associated protein 1 ( KEAP1 ), and bi-allelic inactivation of cyclin-dependent kinase inhibitor 2A ( CDKN2A ) and cyclin-dependent kinase inhibitor 2A ( CDKN2B ) have been identified as three major co-occurring genetic alterations in KRAS -mutant LUAD

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These medications work by targeting neurotransmitter systems in the brain involved in nicotine dependence, helping to reduce cravings and withdrawal symptoms