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References Jones WS, Mulder H, Wruck LM, et al., on behalf of the ADAPTABLE Team

In practice, the long-acting GLP-1 RAs became preferred for general glycemic control due to convenience and greater A1c reduction, whereas short-acting ones like lixisenatide found a niche in combination products or for targeting post-meal glucose excursions (for instance, some use lixisenatide mainly to handle breakfast hyperglycemia)

Recent data from a review in Obesity Pillars (2024) highlight how important it is to try food sequencing. Research shows that eating protein and fiber before carbohydrates in a meal significantly enhances GLP-1 secretion and slows down gastric emptying

Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands