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A large proportion had no prior evidence of GLP-1-based medications, highlighting the potential for oral formulations to expand access beyond patients already receiving injectable therapies

Abbreviations AIWG: Antipsychotic-induced weight gain AP(s): Antipsychotic(s) BMI: Body mass index BPRS: Brief Psychiatric Rating Scale CI: Confidence interval DM2: Diabetes mellitus type 2 ESM: Experience sampling method GLP-1: Glucagon-like peptide-1 HbA1c: Glycated haemoglobin HDL: High-density lipoprotein IRB: Institutional review board KQOL: Kemp Quality of Life scale LDL: Low-density lipoprotein MOSA: Management of Obesity with Semaglutide in AIWG NMA: Network meta-analysis QoL: Quality of life SMI: Severe mental illness UKU-SERS: UKU-Side Effect Rating Scale References van Alphen C, Ammeraal M, Blanke C, Boonstra N, Boumans H, Bruggeman R, et al

In this same trial, taking semaglutide was associated with reduced risk factors for cardiovascular disease, including blood pressure, waist circumference, lipids, and inflammatory markers

Maridebart cafraglutide (known as MariTide) was a candidate to demonstrate significant efficacy in a once-monthly dosage regimen, with an average weight loss of 17% in patients at 52 weeks, with no plateau in weight loss