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The cardiovascular benefits, including reductions in MACE and stroke, also accumulate over time, with the most substantial gains observed within the first 24 to 36 months of treatment [124, 125]

A 2026 UCL study published in BMC Medicine found that around 1.6 million adults in England, Wales, and Scotland used a GLP-1 weight-loss drug in the year to early 2025

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: 2016 UpToDate Summary adjunct therapy to reduce Hb A1c levels in patients with Type 2 diabetes who are inadequately controlled by other hypoglycemic agents