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Therefore, we used metformin as a control for the secondary analysis

Benefits of LixiLan, a Titratable Fixed-Ratio Combination of Insulin Glargine Plus Lixisenatide, Versus Insulin Glargine and Lixisenatide Monocomponents in Type 2 Diabetes Inadequately Controlled on Oral Agents: The LixiLan-O Randomized Trial

doi: 10.1210/en.2017-00564

In vitro experiments found compound 31 (Figure 5) to be the most potent, as predicted by in-silico simulations, with an IC 50 of 3.16 M