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Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity

Am J Physiol Endocrinol Metab (2013) 305(2):E16170

A new peer-reviewed in vitro study using the standardized INFOGEST digestion model revealed Pepzyme AG promotes enhanced collagen breakdown and increased release of low-molecular-weight bioactive peptides, helping consumers utilize collagen more efficiently