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In the absence of such disclosure, the public must rely on sponsors to voluntarily share information on why a marketing authorization application was not approved, which is an unreliable source given that sponsors are not required to disclose this information and, as evidenced by the lack of press releases in response to complete response letters, may have strong disincentives for public sharing (Lurie et al., 2015)

All three databases capture de-identified, longitudinal patient-level information on demographics

Cortisol rises, cravings intensify, and stress eating becomes a genuine biological responsenot a lack of willpower

Galien, R