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The blood samples were analysed to assess the complete blood count and parameters related to iron metabolism, including iron and ferritin concentration, unsaturated ironbinding capacity (UIBC) and total ironbinding capacity (TIBC)

Additionally, GLP-1 receptor agonists may exert direct anti-inflammatory effects on hepatic tissue, though the clinical significance of these direct effects remains under investigation

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Individuals with the following conditions may be at heightened risk and should be assessed carefully: Pre-existing arrhythmias , including atrial fibrillation or supraventricular tachycardia, given the drug's association with elevated resting heart rate Heart failure , particularly where heart rate control is a key management goal Ischaemic heart disease , where any increase in myocardial oxygen demand could be clinically significant Uncontrolled hypertension , although retatrutide may itself reduce blood pressure over time Patients on rate-modifying medications such as beta-blockers or calcium channel blockers whilst no direct pharmacokinetic drugdrug interactions have been established, the heart rate effects of retatrutide may complicate clinical management and require closer monitoring Patients with a recent acute coronary syndrome, decompensated heart failure, or unstable angina are typically excluded from clinical trials of this class of agent