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"In the enhanced comps, I'd say the vast majority of people would use some sort of pharmaceutical that aids in fat loss," he said

GLP-1R is expressed at both the mRNA and protein levels across a diverse array of tissues, including the lungs, vasculature, pancreatic islets and acini, gastrointestinal tract, kidneys, gonads, urogenital system, and thyroid [40, 52]

Tirzepatide is a dual GIP/GLP-1 receptor agonist used for type 2 diabetes (Mounjaro) and weight management (Zepbound), administered weekly by subcutaneous injection

Anecdotally, some users have reported that combining them increases dizziness and intensifies the intoxicating effects of cannabis