oasis 1 trial oral semaglutide 50 mg obesity nejm 2023 Frontiers Orforglipron, an Oral Small-Molecule GLP-1
Description
The Wayne State / Brooklyn College work does not build on those in vivo results directly, but the two papers together suggest the transdermal route is reproducibly reaching the tissue layer that matters, at least in preclinical conditions

Intratumoral concentrations and effects of orally administered micellar curcuminoids in glioblastoma patients
The monounsaturated fatty acid oleic acid in olive oil also stimulates production of oleoylethanolamide (OEA), a gut-derived lipid messenger that enhances satiety

95% CI 0.38 0.99
