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In a pilot trial evaluating 104 amnestic MCI and early-stage AD patients, 20 IU and 40 IU doses of intranasal insulin improved Alzheimers Disease Assessment Scale-Cognitive subscale (ADAS-Cog 12) scores compared to placebo-treated patients, with improvements in delayed recall observed 2 months following cessation of treatment in the 20 IU group

Rorth R, Jhund PS, Mogensen UM, Kristensen SL, Petrie MC, Kober L, McMurray JJV
This is a genuine mechanistic advantage of keto for people on semaglutide

GLP-1RAs improve IR primarily by enhancing the muscle cell sensitivity to insulin
